| Registro completo |
| Provedor de dados: |
BABT
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| País: |
Brazil
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| Título: |
Biodistribution of free 99mTc-ovalbumin and 99mTc-ovalbumin encapsulated in liposomes
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| Autores: |
Alves,Andrea Catão
Gontijo,Cristiano Machado
Oliveira,Mônica Cristina
Diniz,Simone Odília Fernandes
Oliveira,Flávia Márcia
Cardoso,Valbert Nascimento
Ramaldes,Gilson Andrade
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| Data: |
2005-10-01
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| Ano: |
2005
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| Palavras-chave: |
Liposomes
Oral absorption
Mucosal delivery
Proteins
Nanotechnology
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| Resumo: |
The oral administration of proteic antigens, like ovalbumin, may result in the induction of oral tolerance or immunization. The aim of this work was to label a protein antigen with 99mTechnetium, encapsulate it in liposomes and investigate its absorption and tissue distribution after oral administration in mice. Ovalbumin was labeled with 99mTechnetium and encapsulated in small unilamellar vesicles. 99mTc-OVA encapsulated or not in liposomes was administrated to mice that were sacrificed after different times. The radioactivity was measured in various organs of the animals. Differences concerning the biodistribution of 99mTc-OVA were noticed. The technique may represent alternatives for the induction of immunization or oral tolerance.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000700035
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| Editor: |
Instituto de Tecnologia do Paraná - Tecpar
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| Relação: |
10.1590/S1516-89132005000700035
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| Formato: |
text/html
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| Fonte: |
Brazilian Archives of Biology and Technology v.48 n.spe2 2005
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| Direitos: |
info:eu-repo/semantics/openAccess
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